2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoicacid
BIBR 1532
CAS: 321674-73-1
Molecular Formula: C21H17NO3
2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoicacid - Names and Identifiers
2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoicacid - Physico-chemical Properties
| Molecular Formula | C21H17NO3 |
| Molar Mass | 331.36 |
| Density | 1.284 |
| Melting Point | >173oC (dec.) |
| Boling Point | 600.6±48.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 3.46±0.36(Predicted) |
| Storage Condition | Store at RT |
| Use | BIBR 1532 is an effective, selective, non-competitive telomerase inhibitor with an IC50 of 100 nM. |
| In vitro study | In vitro, BIBR 1532 noncompetitively inhibited telomerase activity in a dose-dependent manner with an IC50 of 100 nM. BIBR 1532 has an antiproliferative effect on JVM13 leukemic cell line in a dose-dependent manner with an IC50 of 52 μm and on other leukemic cell lines, including Nalm-1, HL-60, and Jurkat had similar results. In addition, BIBR 1532 acts on acute myeloid leukemia (AML) and has an antiproliferative effect with an IC50 of 56 μm without affecting the proliferative capacity of normal hematopoietic stem cells. BIBR 1532 (2.5 μm) acts on MCF-7/WT and anti-Melphalan MCF-7/ml NR cell lines to reduce the ability to form colonies and shorten telomere length by inhibiting telomerase activity, and the induction of chemotherapy sensitization. BIBR 1532 has selective cytotoxicity against T-cell prolymphocytic leukemia (T-PLL) in a dose-dependent manner, and BIBR 1532 treated cells also showed nuclear concentration, and the formation of apoptotic bodies. In vitro, BIBR 1532 noncompetitively inhibited telomerase activity in a dose-dependent manner with an IC50 of 100 nM. BIBR 1532 has an antiproliferative effect on JVM13 leukemic cell line in a dose-dependent manner with an IC50 of 52 μm and on other leukemic cell lines, including Nalm-1, HL-60, and Jurkat had similar results. In addition, BIBR 1532 acts on acute myeloid leukemia (AML) and has an antiproliferative effect with an IC50 of 56 μm without affecting the proliferative capacity of normal hematopoietic stem cells. BIBR 1532 (2.5 μm) MCF-7/ML n BIBR 1532 against MCF-7/WT and anti-Melphalan on T-cell prolymphocytic leukemia (T-PLL) with selective cytotoxicity in a dose-dependent manner, BIBR 1532 treated cells also showed nuclear condensation and formation of apoptotic bodies. |
2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoicacid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.018 ml | 15.089 ml | 30.179 ml |
| 5 mM | 0.604 ml | 3.018 ml | 6.036 ml |
| 10 mM | 0.302 ml | 1.509 ml | 3.018 ml |
| 5 mM | 0.06 ml | 0.302 ml | 0.604 ml |
Last Update：2024-01-02 23:10:35
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Product Name: BIBR 1532 Visit Supplier Webpage Request for quotationCAS: 321674-73-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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